South Carolina vs. Kentucky: Game info, how to watch, betting odds, and prediction

South Carolina faces Kentucky in a primetime SEC clash at Williams-Brice Stadium. Kickoff, TV channel, and prediction.
South Carolina v Kentucky
South Carolina v Kentucky | Michael Hickey/GettyImages

The South Carolina Gamecocks return home to Williams-Brice Stadium on Saturday night to host the Kentucky Wildcats in a pivotal SEC matchup. Kentucky (2-1) will make their first road trip of the 2025 season. Mark Stoops' team comes in off of a conference loss to Ole Miss, but the Wildcats still have the confidence behind a very physical defense and a balanced offense. South Carolina (2-2) is looking to steady itself after back-to-back SEC losses. The Gamecocks opened the season with wins over Virginia Tech and SC State before hitting turbulence against Vanderbilt and Missouri. Head coach Shane Beamer knows the margin of error is slim if South Carolina wants to keep pace with last year's 9-win season.

Game Information

  • Date: Saturday, September 27, 2025
  • Kickoff: 7:45 p.m. ET
  • Location: Williams-Brice Stadium, Columbia, S.C.
  • TV: SEC Network

Kentucky vs. South Carolina Odds

  • Spread: South Carolina favored by 6.5 points
  • Over/Under (Total Points): ~ 46.5 points
  • Moneyline:
     • South Carolina: ~ –230 to –270
     • Kentucky: ~ +180 to +210
  • Line movement / Consensus: Multiple sportsbooks (FanDuel, DraftKings) mirror the 6.5-point line.

Series History

The Gamecocks lead the all-time series 21-14-1. South Carolina has won three straight games over Kentucky, including last season's meeting. Notably, Kentucky's 2021 win was later vacated due to NCAA violations.

What's at Stake

For South Carolina, quarterback LaNorris Sellers continues to lead the charge as the offense looks for consistency A win would stabilize the season and restore momentum heading into the teeth of SEC play. For Kentucky, a victory would snap a six-game conference losing streak and inject needed confidence back into the Wildcats squad before a brutal three-game stretch against Georgia, Texas, and Tennessee.

Expect a tight, physical game under the lights in Columbia. Sellers. Prediction: The Gamecocks' defense make just enough plays to extend Kentucky's SEC woes and protect their home turf.